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poly vinyl pyrrolidone

Polyvinylpyrrolidone

CAS: 9003-39-8

Molecular Formula: (C6H9NO)n

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poly vinyl pyrrolidone - Names and Identifiers

Name Polyvinylpyrrolidone
Synonyms PVP
K-30
PVP-K
PVP-K30
PVP-K17
PVP-K25
PVP-K90
Povidone
PVP K 30
Crospovidone
Polyinylpyrrolidone
Polyvinylpyrrolidine
Polyvinylpyrrolidone
Polyvinglpyrrolidone
Polyvinyl pyrrolidone
poly vinyl pyrrolidone
CAS 9003-39-8
EINECS 1312995-182-4

poly vinyl pyrrolidone - Physico-chemical Properties

Molecular Formula(C6H9NO)n
Molar Mass111.143
Density1,69 g/cm3
Melting Point130℃
Boling Point90-93 °C
Water Solubility>=10 g/100 mL at 20 C
AppearanceWhite powder
Storage ConditionRoom Temprature
Physical and Chemical Properties

Melting Point: 130°C

UseUsed as stationary liquid for gas chromatography

poly vinyl pyrrolidone - Risk and Safety

Safety DescriptionS24/25 - Avoid contact with skin and eyes.

poly vinyl pyrrolidone - Upstream Downstream Industry

Raw MaterialsEthanolamine
1,3-BUTADIENE
1,4-Butanediol
N-Vinyl-2-pyrrolidone

poly vinyl pyrrolidone - Reference

Reference
Show more
1. Zhao-Yang Liu, Yongxin song, Tianshu Wang, Gui-Han single. Preparation of histidine-modified Prussian blue and its interaction with silver ion [J]. Chemical Journal of Chinese universities, 2020,41(07):1492-1498.
2. Shi Qingping, Zhang Zhitao, Ding Feng, et al. Optimization of the prescription of total diosgenin orally disintegrating tablets by Central composite design-response surface methodology [J]. Chinese traditional medicines, 2014, 36(012):2508-2512.
3. Wang Jie, King Kong, Xue Jianfei, etc. Preparation and in vitro dissolution of pioglitazone hydrochloride Solid Dispersion [J]. Mass Technology, 2015, 17(012):37-38.
4. Wang Jie, Sun Yang, King Kong, etc. Effect of alkaline modifier on dissolution of nifedipine solid dispersion in vitro [J]. Shandong chemical industry, 2015(22).
5. Wang Jie, Sun Yang, King Kong, etc. Effect of alkaline regulator on dissolution of valsartan solid dispersion in vitro [J]. Journal of Jilin Institute of Chemical Technology, 2015, 000(011):30-33.
6. He Junhua, Marley Jing, Zhou Huiling. Effects of phlorizin on Botrytis cinerea of postharvest Apple [J]. Food Science, 2018, 039(015):190-196.
7. Zhang Liping, Ji Shujuan. Effects of different treatments after cold storage on Esters and key enzymes of ethylene synthesis in Nanguo pear treated with 1-MCP [J]. Food Science, 2013(24):285-288.
8. Luo Zheng, Guo Yuan-yuan, Chen Fei-ping, et al. Inhibition of key enzyme phenylalanine in lignification of Brassica campestris L. By high oxygen modified atmosphere packaging [J]. Food Research and Development, 2019, 40(08):36-40.
9. Wang Jie, Wang dujun, Li Fengwei, etc. Optimization of conditions for enrichment of γ-aminobutyric acid and flavonoids from Salicornia seed germination and study on key enzyme activities [J]. Food Research and Development, 2019, v.40;No.372(23):66-73.
10. Ji Shujuan, Dong Ling, Zhou Xin, Li Rui, Cheng Shunchang. Effect of salicylic acid on ester aroma of Nanguo pear treated with 1-MCP during cold storage and its mechanism [J]. Chinese Journal of Food Science, 2016,16(06):167-173.
11. Xie Weijie, Zhang Yongping, Xu Jian. Screening Matrix formulation of indomethacin hydrophilic gel patch by uniform design [J]. China Pharmacy, 2017(10).
12. Zhang Yongping, Xu Jian, Xie Weijie. Optimization of matrix formulation and molding process of indomethacin hydrophilic gel patch by Central composite design-response surface methodology [J]. Medical Review, 2018, 037(005):593-599.
13. Zhang Liping, Ji Shujuan. Effects of ethephon on aroma and key enzyme activities during aroma synthesis of Nanguo pear treated with 1-MCP during cold storage [J]. Food Science, 2013, 34(10):294-298.
14. Zhang ningying, Chen Haiyan, Chen Hangjun. Effects of Ozone treatment on storage quality and antioxidant enzyme activities of blueberry [J]. Chinese Journal of Food Science, 2017, 17(008):170-176.
15. Li Xiaoting Bai Yubin Li Bing et al. Study on the compatibility of excipients for compound suspension of pentachlorosamine and albendazole [J]. Animal and Veterinary Science v.51;No.407(06):57-62.
16. Xu Liqing, Zhang Liyan. Preparation and quality evaluation of Candesartan Cilexetil polyvinylpyrrolidone K30 coprecipitate dispersible tablets [J]. Northwest Pharmaceutical Journal, 2021,36(01):81-86.
17. Liu Hongbo, Xu Sining, Tang Zhishu, Sun Jing, Song Zhongxing, Cui Chunli, Yu Jin Gao, Shi Xinbo, Sun Xiaochun. Optimization and in vitro evaluation of Qinqi rheumatism prescription gel matrix components [J]. Chinese new drugs and clinical pharmacology, 2020,31(10):1233-1238.
18. Chen Shaojun, Ding Bo, Ding Anli, Li Chunlai. Surfactant-assisted hydrothermal synthesis of Lini_(1/3) co_(1/3) mn_(1/3)O_2 cathode materials [J]. New chemical materials, 2020,48(09):96-99 104.
19. Yang Mingtong. Design, preparation and application of titanium based metal oxide nano materials in Lithium Sulfur batteries [D]. Nanjing University of Posts and Telecommunications, 2020.
20. Zhang, H., xu, H., li, Y. et al. Nanocable catalysts MTe (M = Pt, PtCu)@ UIO-67 for CO2 conversion. Sci. China Mater. 63, 769-778 (2020). https://doi.org/10.1007/s40843-019-1258-8
21. Cheng, Xu, et al. "Bimetallic metal-organic frameworks nanocages as multi-functional fillers for water-selective membranes." Journal of Membrane Science 545 (2018): 19-28.https://doi.org/10.1016/j.memsci.2017.09.056
22. Wu, Mingxin, et al. "Assisted 3D printing of microneedle patches for minimally invasive glucose control in diabetes." Materials Science and Engineering: C 117 (2020): 111299.https://doi.org/10.1016/j.msec.2020.111299
23. Wei, S ., Li, J., He, J. et al. Paper chip-based colorimetric assay for detection of Salmonella typhimurium by combining aptamer-modified Fe3O4@Ag nanoprobes and urease activity inhibition. Microchim Acta 187, 554 (2020). https://doi.org/10.1007/s00604-020-
24. Feng, Shuxuan, et al. "Maskless patterning of biodegradable conductors by selective laser sintering of microparticle inks and its application in flexible transient electronics." ACS applied materials & interfaces 11.49 (2019): 45844-45852.https://doi.org/1
25. Zhang, Li‐Ping, et al. "Effects of 1‐methylcyclopropene on the Metabolic Pathways of Aroma‐Related Compounds in N anguo Pear." Journal of Food Processing and Preservation 38.4 (2014): 1749-1758.https://doi.org/10.1111/jfpp.12138
26. Wei, Yulong, et al. "Exploring the biochemical properties of three polyphenol oxidases from blueberry (Vaccinium corymbosum L.)." Food Chemistry 344 (2021): 128678.https://doi.org/10.1016/j.foodchem.2020.128678
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28. [IF=2.19] Li-Ping Zhang et al."Effects of 1-methylcyclopropene on the Metabolic Pathways of Aroma-Related Compounds in Nanguo Pear."J Food Process Pres. 2014 Aug;38(4):1749-1758
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poly vinyl pyrrolidone - Nature

Open Data Verified Data

white powder, with slightly odor. Hygroscopic. Soluble in water, ethanol, ether and other organic solvents. For a variety of substances have a strong ability to complex adsorption.

Last Update:2024-01-02 23:10:35

poly vinyl pyrrolidone - Preparation Method

Open Data Verified Data

The product is obtained by polymerizing n-vinyl-2-pyrrolidone in the presence of a basic catalyst or N,N'-vinyltriazole, followed by purification.

Last Update:2022-01-01 10:10:03

poly vinyl pyrrolidone - Standard

Authoritative Data Verified Data

This product is obtained by polymerizing pyrrolidone and ethylene under pressure to form a vinyl pyrrolidone monomer by the action of a catalyst. 1-vinyl-2-pyrrolidone homopolymer having an average molecular weight of 3.8x 104 and a molecular formula of (C6H9NO)n, where n represents the average number of 1-vinyl-2-pyrrolidone moieties.

Last Update:2024-01-02 23:10:35

poly vinyl pyrrolidone - Trait

Authoritative Data Verified Data
  • This product is white to milky white powder; Odorless or slightly odorous, tasteless; With hygroscopicity.
  • This product is soluble in water, ethanol, isopropanol or chloroform, and insoluble in acetone or ether.
Last Update:2022-01-01 11:28:02

poly vinyl pyrrolidone - Use

Open Data Verified Data

used as a colloidal stabilizer and clarifier, can be used for the clarification of beer, according to the production needs of the appropriate amount of use.

Last Update:2022-01-01 10:10:03

poly vinyl pyrrolidone - Differential diagnosis

Authoritative Data Verified Data
  1. take 2ml of this product aqueous solution (1-50), add 2ml of lmol/L hydrochloric acid solution and several drops of potassium dichromate solution, and generate orange-yellow precipitate.
  2. take 3ml of this product aqueous solution (1-50), add about 15mg of cobalt nitrate and about 75mg of ammonium thiocyanate. After stirring, add dilute hydrochloric acid Dropwise to make it acidic, which generates light blue precipitate.
  3. take 3ml of this product aqueous solution (1-50) and add 1-2 drops of test solution to generate brown-red precipitate, which is stirred and dissolved into brown-red solution.
Last Update:2022-01-01 11:28:03

poly vinyl pyrrolidone - Safety

Open Data Verified Data

sealed and preserved at room temperature, dry and protected from light.

Last Update:2022-01-01 10:56:45

poly vinyl pyrrolidone - Exam

Authoritative Data Verified Data

k value

take L. 00g of this product (calculated as anhydrous), weigh it accurately, put it in a 100ml measuring flask, add appropriate amount of water to dissolve it, after placing in a constant temperature water bath at 25°C ± 0.05°C for 1 hour, add water to dilute to the scale, check according to law (General rule 0633 method), and measure the relative viscosity to calculate the k value according to the following formula, should be 27.0 to 32.0.


pH

take this product 1.0g (calculated by anhydrous), add water 20ml dissolved, check according to law (General rule 0631), pH value should be 3.0-7.0.


aldehyde

take about 20.0g of this product (calculated as anhydrous), put it in a round-bottom flask, add 4.5mol/L sulfuric acid solution, heat and reflux for 45 minutes, and let it cool; separately take hydroxylamine hydrochloride solution (take hydroxylamine hydrochloride 6.95g, add water to dissolve and dilute to 100ml, adjust pH value to 3.1ml with ammonia test solution) 20ml, put the Erlenmeyer flask, then place the Erlenmeyer flask in ice bath, connect the distillation device, the lower end of the condenser tube was inserted under the liquid surface of the human hydroxylamine hydrochloride solution, and heated for distillation. When the total volume of the receiving liquid was about 120ml, the distillation was stopped, and the distillate was titrated with sodium hydroxide solution (O .lmol/L) titration to pH value of 3.1, and the titration results with blank test correction, consumption of sodium hydroxide titration solution (0.lmol/L) shall not exceed 9.lml.


N-vinylpyrrolidone

take 10.0g of this product (calculated as anhydrous), add water 80ml to dissolve, add sodium acetate lg, precision Iodine titration solution (0.05mol/L)10ml, place for 10 minutes, with sodium thiosulfate titration solution (O.lmol/L) titration, when the end point is reached, add 2ml of starch indicator solution, continue titration until the blue color disappears, and correct the titration result with blank test, consumption of Iodine titration solution (0.05mol/L) should not exceed 3.6.


moisture

take this product, according to the determination of moisture (General 0832), the water content shall not exceed 5.0%.


ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.


Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).


nitrogen content

take this product about O.lg, precision weighing, put in the Kjeldahl nitrogen determination bottle, add potassium sulfate log and copper sulfate 0.5g successively, slowly add 20ml sulfuric acid along the wall of the bottle, put a small funnel at the mouth of the Kjeldahl nitrogen determination bottle, slowly heat with direct fire, once the solution had a clear green color, heating was continued for 30 minutes and allowed to cool. Transfer to a 100ml measuring flask, dilute to the scale with water, and shake. The distillate is titrated with a sulfuric acid titration solution (0704 mol/L) and the titration result is corrected with a blank test by precisely sucking 10ml and measuring according to the nitrogen determination method (General rule 0.005 second method). The nitrogen content should be between 11.5% and 12.8%, calculated as anhydrous.

Last Update:2022-01-01 11:28:04

poly vinyl pyrrolidone - Category

Authoritative Data Verified Data

pharmaceutical excipients, adhesives and cosolvents.

Last Update:2022-01-01 11:28:04

poly vinyl pyrrolidone - Storage

Authoritative Data Verified Data

light-shielded, sealed, and stored in a dry place.

Last Update:2022-01-01 11:28:04

poly vinyl pyrrolidone - Nature

storage conditions 2-8°C
solubility H2O: soluble100mg/mL
morphology powder
color White to yellow-white
PH value 3.0-5.0
water solubility Soluble in water.
sensitivity Hygroscopic
Merck 14,7697
stability Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
(IARC) Carcinogen Classification 3 (Vol. 19, Sup 7, 71) 1987
EPA chemical information Polyvinylpyrrolidone (9003-39-8)
Last Update:2024-04-10 22:29:15

poly vinyl pyrrolidone - Security information

WGK Germany 1
RTECS number TR8370000
auto-ignition temperature 440 °C
TSCA Yes
customs code 39059990
toxic substance data 9003-39-8(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
Last Update:2024-04-10 22:29:15
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View History
poly vinyl pyrrolidone
4,5-环氧青蒿酸
6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE, 97
STAYBELITE ESTER 5
CETETHYLDIMONIUM BROMIDE
chlorhydratedeacetoxy-thymoxy-ethyl-dimethylamine
4-(2-氨基苯基)吡啶
N-Benzyl-3-(hydroxymethyl)morpholine
Fluoxetine Impurity 2(EP-B)
2-methylpropyl benzoate
Raw Materials for poly vinyl pyrrolidone
Ethanolamine
1,3-BUTADIENE
1,4-Butanediol
N-Vinyl-2-pyrrolidone
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